How does hyaluronidase function when injected as a response to extravasation?

Hyaluronidase functions primarily by enhancing fluid absorption in the space where it is injected, particularly in cases of extravasation, which is the leakage of fluid out of blood vessels into surrounding tissue. By breaking down hyaluronic acid, a component of the extracellular matrix, hyaluronidase facilitates the dispersion and absorption of fluids that may have accumulated due to extravasation.

This enzymatic action helps to restore normal tissue dynamics, allowing excess fluid to be reabsorbed into the vascular system more efficiently. The reduction of localized swelling can occur as a secondary effect, but the primary mechanism is indeed the enhancement of fluid absorption, making hyaluronidase an effective treatment in managing complications associated with extravasation.