In what situation is a biopsy of the margin of a non-healing ulcer performed?

A biopsy of the margin of a non-healing ulcer is appropriately performed after venous insufficiency has been successfully treated to assess for any underlying pathology that may be contributing to the ulcer's inability to heal. When venous insufficiency is treated, the circulation in the affected area improves, which can provide a clearer view of the ulcer's margins and allow for a more accurate assessment of the tissue.

This timing is crucial because performing a biopsy before addressing the underlying condition may yield misleading information or cause further complications. By first treating venous insufficiency, the clinician ensures that the environment around the ulcer is optimal for healing and can more reliably evaluate the tissue characteristics, allowing for a definitive diagnosis if there are signs of malignancy or other pathologies in the biopsy results.

This approach underscores the importance of managing underlying conditions in wound care, ensuring that all factors contributing to the non-healing ulcer are duly considered before invasive diagnostic measures are taken.