Lateral ankle telangiectasia is most commonly associated with:

Lateral ankle telangiectasia is primarily associated with the short saphenous vein (SSV) reflux, making this the correct answer. The SSV, which runs along the posterior aspect of the leg and drains into the popliteal vein, can lead to venous insufficiency in the lower extremities. When there is reflux occurring in the SSV, the resulting venous hypertension can manifest as telangiectasia in locations such as the lateral ankle.

Telangiectasia, which are small, dilated blood vessels, can become prominent in areas affected by venous insufficiency, and their presence near the ankle is a clinical indication of underlying problems with venous drainage, particularly involving the SSV.

Understanding the vascular anatomy and the pattern of venous disease helps in recognizing the significance of lateral ankle telangiectasia specifically in relation to SSV reflux, connecting the clinical observation to physiological changes in venous circulation.