What condition contributes to the increased permeability of the vein wall that results in lipodermatosclerosis?

The condition that contributes to increased permeability of the vein wall, leading to lipodermatosclerosis, is venous hypertension. When the veins become abnormally high in pressure, it can weaken the walls of the veins. This heightened pressure causes the delicate balance between hydrostatic pressure and osmotic pressure to be disrupted. Consequently, the endothelial cells lining the blood vessels become more permeable, allowing fluid and plasma proteins to leak into surrounding tissues, leading to inflammation and ultimately lipodermatosclerosis.

Lipodermatosclerosis is characterized by changes in the skin and underlying tissue that occur due to chronic venous insufficiency. The elevated venous pressure creates a cascade of events that results in the thickening of the skin, deposits of fat, and other changes that lead to the characteristic appearance of the lower leg.