What is a significant characteristic of patients with antiphospholipid antibody syndrome (APAS)?

Patients with antiphospholipid antibody syndrome (APAS) have a notable characteristic of having a 30% lifetime risk of experiencing a thrombotic event. This higher risk is associated with the presence of antiphospholipid antibodies, which can lead to an increased tendency for thrombosis, both venous and arterial. The antibodies interfere with the normal regulatory mechanisms of coagulation, resulting in various complications, particularly in young individuals.

Thrombotic events can manifest as deep vein thrombosis, pulmonary embolism, and even stroke. Understanding this risk is vital for management and prophylactic strategies in these patients to prevent potentially life-threatening events.